Synthesis of Triazafluoranthenones via Silver(I)-Mediated Nonoxidative and Oxidative Intramolecular Palladium-Catalyzed Cyclizations

Synthesis of heterocycles via palladium-catalyzed oxidative addition.

Palladium-catalyzed processes have proven to be a powerful and useful tool for the synthesis of heterocycles. Palladium has found such wide utility because it affects an extraordinary number of very different reactions, including many carbon-carbon bond-forming reactions, under relatively mild reaction conditions. Furthermore, palladium can usually be used in only catalytic amounts and tolerate...

Regioselective synthesis of oxazole derivatives via palladium-catalyzed and copper-mediated cascade oxidative cyclization.

A novel Pd-catalyzed/Cu-mediated oxidative cyclization has been developed for the synthesis of trisubstituted oxazoles, which is thought to proceed through cascade formation of C-N and C-O bonds. In this protocol, four hydrogen atoms were removed and water was used as the oxygen atom source.

Regioselective palladium-catalyzed intramolecular oxidative aminofluorination of unactivated alkenes.

A novel Pd-catalyzed regioselective intramolecular aminofluorination of unactivated alkenes has been developed, which is an efficient method for the synthesis of a variety of monofluoromethylated nitrogen-containing heterocycles.

Synthesis of heterocycles via palladium-catalyzed carbonylations.

Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination.

A novel palladium-catalyzed intramolecular reductive amination of ketones with weakly nucleophilic sulfonamides has been developed in the presence of a Brønsted acid, giving a wide range of chiral γ-, δ-, and ε-sultams in high yields and up to 99% of enantioselectivity.